hHER2

Nomenclature

C57BL/6Smoc-Erbb2tm1(hERBB2)Smoc

Cat. NO.

NM-HU-200115

Strain State

Repository Live

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Gene Summary

Gene Symbol
Erbb2

Synonyms

Neu; HER2; HER-2; c-neu; Erbb-2; c-erbB2; l11Jus8; mKIAA3023

NCBI ID

13866

MGI ID

95410

Ensembl ID

ENSMUSG00000062312

Pubmed

Erbb2

Human Ortholog

ERBB2

Model Description

The endogenous mouse Erbb2 gene was replaced by human ERBB2 gene.
Research Application：Immune-related; tumor research; drug screening

Validation Data

image.png

Fig1. Detection of HER2 expression by RT-PCR. 

Wild type: only one band at 375 bp with primers F1/R1 (mHer2);

Homozygous: one band at 223 bp with primers F2/R2 (hHER2).

Abbr. M, DNA marker; HO, homozygous;  WT, wild type.

image.png

Fig2. Detection of HER2 expression in homozygous hHER2 mice by Western Blot. 

(Note: The HER2 antibody cross-reacted with mHER2 and humanized HER2)

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