Slc32a1-IRES-Cre

Nomenclature

C57BL/6Smoc-Slc32a1em1(IRES-iCre)Smoc

Cat. NO.

NM-KI-200081

Strain State

Repository Live

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Gene Summary

Gene Symbol
Slc32a1

Synonyms

VGAT; Viaat; R75019

NCBI ID

22348

MGI ID

1194488

Ensembl ID

ENSMUSG00000037771

Pubmed

Slc32a1

Human Ortholog

SLC32A1

Model Description

A IRES-iCre expression cassette was knocked into the Slc32a1 gene stop codon site.
Research Application：Cre recombinase tool; Slc32a1 is a member of the GABA Vesicular Transporter Family. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre. This strain may be useful for studying GABaergic neurons function.

Validation Data

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Fig. 1 Cre-mediated recombination in the brain of Slc32a1Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the cortex, hippocampus, hypothalamus and cerebellum of Slc32a1Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Slc32a1Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the cortex, hippocampus, hypothalamus, cerebellum, retinal ganglion cell layer, retinal outer plexiform layer and inner nuclear layer. TdTomato can also be detected in individual cells of the sailvary gland, kidney, pancreas, large intestine, spleen, thymus, testis and epididymis. Tdtomato expression can not be observed in the heart, lung, liver, small intestine and skin. (For more detailed information please contact our technical advisor.)


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