Aqp5-Cre

Nomenclature

C57BL/6Smoc-Aqp5em1(iCre-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200062

Strain State

Repository Live

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Gene Summary

Gene Symbol
Aqp5

Synonyms

-

NCBI ID

11830

MGI ID

106215

Ensembl ID

ENSMUSG00000044217

Pubmed

Aqp5

Human Ortholog

AQP5

Model Description

A iCre-WPRE-polyA expression cassette was knocked into the Aqp5 gene start codon site.
Research Application：Cre recombinase tool; Aquaporin 5 (AQP5) belongs to a family of water channel proteins that allow water to pass through the plasma membrane by osmosis. AQP5 is expressed in salivary gland and lung epithelial cells. When crossed with a reporter mice, reporter gene expression can be detected in Aqp5 positive cells. When crossed with a strain carrying a gene flanked by loxP sites, the flanked gene will be removed in cells expressing cre.

Validation Data

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Fig. 1 Cre-mediated recombination in the lung of Aqp5Cre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the lung epithelial cells derived from Aqp5Cre/+; Rosa26tdTomato/+ mouse.

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Fig. 2 Detection of tdTomato(red) in various tissues of Aqp5Cre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in lung epithelial cells, salivary gland, pancreas, brain, stomach, large intestine and esophagus. TdTomato can also be detected in individual cells of the heart, kidney, spleen, ovary and uterus. (For more detailed information please contact our technical advisor.)


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