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U-GEMMs

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Mice

Pten-Flox

Strain Name：C57BL/6Smoc-Ptenem1(flox)Smoc
Strain State：Repository Live | Cat. NO.：NM-CKO-18004

These Pten flox mice possess loxP sites flanking exons 5 via CRISPR/Cas mediated recombination. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of the gene.

Mice

hOX40

Strain Name：C57BL/6Smoc-Tnfrsf4em1(hTNFRSF4)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-00041

The endogenous mouse Tnfrsf4(Ox40) gene was replaced by human TNFRSF4(OX40) gene. While hOX40(2)(Stock No.NM-HU-00078) mice function similarly to hOX40 mice,for more detailed information please contact our technical advisor.

Mice

hBTLA(2)

Strain Name：C57BL/6Smoc-Btlaem2(hBTLA)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-190040

Extracellular domain of mouse Btla gene was replaced by human BTLA gene. While hBTLA mice(Stock No.NM-HU-18014）have been pulled from shelves for some reasons.

Mice

hPD-1/hPD-L1

Strain Name：C57BL/6Smoc-Pdcd1em1(hPDCD1)Cd274em1(hPD-L1)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-00100

hPD-1(NM-HU-00015) was crossed with hPD-L1(NM-HU-00062)to generate hPD-1/hPD-L1 mice

Mice

H11-pT3(b)-hIL15-Flag

Strain Name：C57BL/6Smoc-Igs2em(pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA-pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA)Smoc
Strain State：Sperm cryopreservation | Cat. NO.：NM-KI-220128

pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA-pT3(b)-Kozak-hIL2 signal peptide-hIL15-Flag-polyA expression cassette was knocked into the the lgs2 (H11) locus.

Mice

HBV-Tg

Strain Name：B6.Cg-Tg(HBV)Smoc
Strain State：Repository Live | Cat. NO.：NM-TG-00003

Full-length HBV genome (adrsubtype,C genotype) was used to establish the transgenic mice. HBsAg was positive in transgenic mice serum; no serum HBeAg anti-HBs, anti-HBe, or antiHBc was detected. No anti-HBs or anti-HBe was detected in the polyethylene gly.

Mice

hANGPTL3(4)

Strain Name：C57BL/6Smoc-Angptl3em1(hANGPTL3)Smoc
Strain State：Repository Live | Cat. NO.：NM-HU-210036

The endogenous mice Angptl3 gene was replaced by human ANGPTL3 gene. While hANGPTL3(Stock No.NM-HU-200113) have been pulled from shelves for some reasons and hANGPTL3(3)(Stock No.NM-HU-210037) mice function similarly to hANGPTL3(2) mice, for more detailed information please contact our technical advisor.

Mice

hOX40/Cd8a-IRES-Luc-2A-EGFP

Strain Name：C57BL/6Smoc-Tnfrsf4em1(hTNFRSF4)Cd8aem1(V5-IRES-luc-2A-EGFP)Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210375

hOX40(NM-HU-00041) was crossed with Cd8a-IRES-Akaluc-2A-EGFP(NM-KI-18030) to generate hOX40/Cd8a-IRES-Akaluc-2A-EGFP mice.

Mice

hAQP4

Strain Name：C57BL/6Smoc-Aqp4em1(hAQP4)/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-210001

The endogenous mice Aqp4 gene was replaced by human AQP4 gene

Mice

Rag2/IL2rg-KO/hSIRPA(2)/hCD47

Strain Name：C57BL/6Smoc-Sirpaem1(hSIRPA)Cd47em1(hCD47)Rag2em1Il2rgem1/Smoc
Strain State：Embryo cryopreservation | Cat. NO.：NM-HU-2000019

The Rag2 and Il2rg genes of the hSIRPA(2)/hCD47 mouse were deleted.

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