Ccl2-KO(2)

Nomenclature

C57BL/6Smoc-Ccl2em1Smoc

Cat. NO.

NM-KO-205027

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Ccl2

Synonyms

JE; HC11; MCAF; MCP1; MCP-1; Scya2; Sigje; SMC-CF; AI323594

NCBI ID

20296

MGI ID

98259

Ensembl ID

ENSMUSG00000035385

Pubmed

Ccl2

Human Ortholog

CCL2

Model Description

Ccl2-KO(2) mice (Stock No.NM-KO-205027） carry a knockout allele derived from the targeted deletion of exon 2-3. While Ccl2-KO mice (Stock No.NM-KO-18025) have been pulled from shelves for some reasons.

Disease Connection

age related macular degeneration

Phenotype(s)

MGI:3814819
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cx3cr1-KO(NM-KO-190065) mice.

Reference(s)

Tuo J, Bojanowski CM, Zhou M, Shen D, Ross RJ, Rosenberg KI, Cameron DJ, Yin C, Kowalak JA, Zhuang Z, Zhang K, Chan CC, Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3827-36

age related macular degeneration

Phenotype(s)

MGI:5527432
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cx3cr1-KO(NM-KO-190065) mice.

Reference(s)

Chen M, Hombrebueno JR, Luo C, Penalva R, Zhao J, Colhoun L, Pandi SP, Forrester JV, Xu H, Age- and light-dependent development of localised retinal atrophy in CCL2(-/-)CX3CR1(GFP/GFP) mice. PLoS One. 2013;8(4):e61381

age related macular degeneration

Phenotype(s)

MGI:3815114

Reference(s)

Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, Rollins BJ, Ambati BK, An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med. 2003 Nov;9(11):1390-7

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