Ace2-KO

Nomenclature

C57BL/6Smoc-Ace2em1Smoc

Cat. NO.

NM-KO-190906

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Ace2

Synonyms

2010305L05Rik

NCBI ID

70008

MGI ID

1917258

Ensembl ID

ENSMUSG00000015405

Pubmed

Ace2

Human Ortholog

ACE2

Model Description

exon 3-7 of Ace2 gene was deleted to generate Ace2 knockout mice.
Research Application：regulation of cardiovascular and renal function, as well as fertility , Cardiac contraction, colitis, cardiovascular and renal function, and fertility

Disease Connection

Congestive Heart Failure

Phenotype(s)

MGI:2661730

Reference(s)

Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM, Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovasc Res. 2007 Jul 1;75(1):29-39

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