Fcgr2b-KO(3)

Nomenclature

C57BL/6Smoc-Fcgr2bem1Smoc

Cat. NO.

NM-KO-210279

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Fcgr2b

Synonyms

AI528646; CD32; F630109E10Rik; Fc[g]RII; FcgRII; Fcgr2; Fcgr2a; Fcr-2; Fcr-3; Ly-17; Ly-m20; LyM-1; Lym-1; fcRII

NCBI ID

14130

MGI ID

95499

Ensembl ID

ENSMUSG00000026656

Pubmed

Fcgr2b

Human Ortholog

FCGR2B

Model Description

Fcgr2b-KO(3) mice (Stock No.NM-KO-210279）carry a knockout allele derived from the targeted deletion of exon 3-5.Fcgr2b-KO mice (Stock No.NM-KO-00130）carry a knockout allele derived from the targeted deletion of exon 3. Fcgr2b-KO(2) mice (NM-KO-191214） have been pulled from shelves for some reasons.

Disease Connection

Cystitis

Phenotype(s)

MGI:5574062
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pd-1-KO(NM-KO-190423) mice.

Reference(s)

Sugino Y, Nishikawa N, Yoshimura K, Kuno S, Hayashi Y, Yoshimura N, Okazaki T, Kanematsu A, Ogawa O, BALB/c-Fcgr2bPdcd1 mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis. Sci Rep. 2012;2:317

Malaria

Phenotype(s)

MGI:2448997

Reference(s)

Clatworthy MR, Willcocks L, Urban B, Langhorne J, Williams TN, Peshu N, Watkins NA, Floto RA, Smith KG, Systemic lupus erythematosus-associated defects in the inhibitory receptor Fc{gamma}RIIb reduce susceptibility to malaria. Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7169-74

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