June 5th 2024

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Why Choose Our F0 Homozygous Mice?

Our new service focuses on non-lethal gene knockout and point mutation Crispr/Cas projects, delivering F0 homozygous mice in just 3 months. Here’s how this can benefit your research:

•   Immediate Phenotype Analysis: Analyze the phenotype of gene deletions or specific mutations directly in F0 mice. This allows you to validate experimental hypotheses early and adjust your research direction swiftly, saving valuable time.

•   Enhanced Research Efficiency: Utilizing homozygous F0 mice can significantly reduce the number of breeding generations required. Combined with IVF, you can quickly expand your mouse population, streamlining your experiments.

•   Cost and Resource Optimization: Obtaining homozygous mice in the F0 generation minimizes the number of animals needed, thereby reducing associated costs and conserving resources.

Our Commitment to Quality

•   Quantity: We provide at least 3 F0 homozygous mice per project.

•   Genotype Confirmation: Genotypes are confirmed using molecular biology techniques such as PCR and sequencing.

•   Health Report: All mice are ensured to be free from specific pathogen infections.

•   Comprehensive Reporting: Each delivery is accompanied by a detailed experiment report.

Limitations and Considerations

•   Non-Applicable Projects:

 • Projects involving gene knockouts that result in embryonic or early postnatal death cannot yield homozygous F0 mice.

 • Genes causing severe developmental defects that prevent mice from surviving to the genotype analysis stage are unsuitable.

•   Important Notes:

 • Chimerism Issues: Gene modification might not be consistent across all cells in F0 homozygous mice, potentially leading to phenotype analysis differences.

 • Survival and Fertility: Severe phenotypes affecting health or survival may pose challenges in obtaining and utilizing these mice for breeding.

 • Indel Variations: Differences in indel variations between alleles can lead to genotype variations in subsequent generations.

 • Off-Target Effects: There is a risk of off-target effects with Crispr/Cas technology, which may result in unexpected phenotypes.

Event Duration

June 1, 2024 - December 31, 2024

Case studies

Case study-1: Generation of Car4-KO mouse model

Case study-2: Generation of Cpa-1-(G＞C) mutant mouse model

How to Order

•   Email Us: service.us@modelorg.us; info@genobiotx.com

•   Direct Contact: Reach out directly to your Business Development Manager

Partner with GenoBioTX today!

Experience a significant boost in your research efficiency and success. Let’s accelerate your breakthroughs together!

For more information or to place an order, contact us today!