MHC Class II(I-A/I-E)-KO(Nod-Scid)

Nomenclature

NOD-PrkdcscidH2-Ab1em1H2-Aaem1H2-Eb1em1H2-Eb2em1H2-Ea-psem1Smoc

Cat. NO.

NM-KO-18057

Strain State

Developing

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Gene Summary

Gene Symbol
H2-Ab1

Synonyms

IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta

NCBI ID

14961

MGI ID

103070

Ensembl ID

ENSMUSG00000073421

Pubmed

H2-Ab1

Human Ortholog

HLA-DQB2

Gene Symbol
H2-Aa

Synonyms

Ia1; H2Aa; Ia-1; H-2Aa; Aalpha; IAalpha; I-Aalpha

NCBI ID

14960

MGI ID

95895

Ensembl ID

ENSMUSG00000036594

Pubmed

H2-Aa

Human Ortholog

HLA-DQA1

Gene Symbol
H2-Eb1

Synonyms

Eb; Ia4; H2Eb; Ia-4; H-2Eb

NCBI ID

14969

MGI ID

95901

Ensembl ID

ENSMUSG00000060586

Pubmed

H2-Eb1

Human Ortholog

HLA-DRB1;HLA-DRB5

Gene Symbol
H2-Ab1

Synonyms

IAb; Ia2; Ia-2; Abeta; H-2Ab; H2-Ab; Rmcs1; I-Abeta; AI845868

NCBI ID

14961

MGI ID

103070

Ensembl ID

ENSMUSG00000073421

Pubmed

H2-Ab1

Gene Symbol
H2-Eb2

Synonyms

Ia5; Ia-5; H-2Eb2; Iebeta2; A130038H09Rik

NCBI ID

381091

MGI ID

95902

Ensembl ID

ENSMUSG00000067341

Pubmed

H2-Eb2

Human Ortholog

H2-EB2

Model Description

All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the Nod-Scid genetic background and lacked cell surface expression of both class II-A and class II-E MHC proteins.
Research Application：immune system

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