Wap-IRES-Cre

Nomenclature

C57BL/6Smoc-Wapem1(IRES-Cre-WPRE-polyA)Smoc

Cat. NO.

NM-KI-200064

Strain State

Repository Live

Export PDF

Gene Summary

Gene Symbol
Wap

Model Description

A IRES-Cre-WPRE-polyA expression cassette was knocked into the Wap gene stop codon site.
Research Application:These mice express cre recombinase from the Wap locus. By mating the reporter mice with Cre-expressing mice, reporter gene expression can be detected in the mammary gland epithelial cells of the lactating mouse. This strain may be useful for in the research of breast carcinoma.

Validation Data

Wap-IRES-Cre-1.png

Fig.1 Cre-mediated recombination in the mammary gland of female WapCre/+; Rosa26tdTomato/+ mouse. TdTomato(red) expression can be detected in the mammary gland epithelial cells of the lactating WapCre/+; Rosa26tdTomato/+ mouse. 

Wap-IRES-Cre-2.png

Fig.2 Detection of tdTomato(red) in various tissues of WapCre/+; Rosa26tdTomato/+ mice. Cre mediated recombination can be detected in the some cells of salivary glands and mammary glands of the lactating mouse. Tdtomato can not be detected in the brain, thymus, pituitary gland, heart, lung, liver, stomach, kidney, brown fats, colon, pancreas, muscle, testis and epididymis. (For more detailed information please contact our technical advisor.)


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more