Xpa-KO

Nomenclature

C57BL/6Smoc-Xpaem1Smoc

Cat. NO.

NM-KO-240559

Strain State

Developing

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Gene Summary

Gene Symbol
Xpa

Synonyms

Xpac; AI573865

NCBI ID

22590

MGI ID

99135

Ensembl ID

ENSMUSG00000028329

Pubmed

Xpa

Human Ortholog

XPA

Model Description

The exon 2-4 of Xpa gene was deleted to generate Xpa knockout mouse.

Disease Connection

Cockayne Syndrome

Phenotype(s)

MGI:3767853
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ercc6-KO(NM-KO-200953) mice.

Reference(s)

van der Pluijm I, Garinis GA, Brandt RM, Gorgels TG, Wijnhoven SW, Diderich KE, de Wit J, Mitchell JR, van Oostrom C, Beems R, Niedernhofer LJ, Velasco S, Friedberg EC, Tanaka K, van Steeg H, Hoeijmakers JH, van der Horst GT, Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol. 2006 Dec 12;5(1):e2

Xeroderma Pigmentosum Group A

Phenotype(s)

MGI:4361117

Reference(s)

Miyauchi-Hashimoto H, Tanaka K, Horio T, Enhanced inflammation and immunosuppression by ultraviolet radiation in xeroderma pigmentosum group A (XPA) model mice. J Invest Dermatol. 1996 Sep;107(3):343-8

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