Cldn16-KO

Nomenclature

C57BL/6Smoc-Cldn16em1Smoc

Cat. NO.

NM-KO-200632

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Cldn16

Synonyms

PCLN1， claudin-16

NCBI ID

114141

MGI ID

2148742

Ensembl ID

ENSMUSG00000038148

Pubmed

Cldn16

Human Ortholog

CLDN16

Model Description

Exon 2 of Cldn16 gene was deleted to generate Cldn16 knockout mice.
Research Application：Sertoli-Sertoli cell junction dynamics and cell junction organization related research

Disease Connection

Renal Hypomagnesemia 3

Phenotype(s)

MGI:4453304

Reference(s)

Will C, Breiderhoff T, Thumfart J, Stuiver M, Kopplin K, Sommer K, Gunzel D, Querfeld U, Meij IC, Shan Q, Bleich M, Willnow TE, Muller D, Targeted deletion of murine Cldn16 identifies extra- and intrarenal compensatory mechanisms of Ca2+ and Mg2+ wasting. Am J Physiol Renal Physiol. 2010 May;298(5):F1152-61

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