Tfam-Flox

Nomenclature

C57BL/6Smoc-Tfamtm1(flox)Smoc

Cat. NO.

NM-CKO-200173

Strain State

Repository Live

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Gene Summary

Gene Symbol
Tfam

Synonyms

Hmgts; mtTFA; tsHMG; AI661103

NCBI ID

21780

MGI ID

107810

Ensembl ID

ENSMUSG00000003923

Pubmed

Tfam

Human Ortholog

TFAM

Model Description

These mice carry loxP sites flanking exon 10-13 of Tfam gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific conditional expression of Tfam gene.
Research Application：Activated PKN1 stimulates the transcription of AR (androgen receptor) regulatory genes KLK2 and KLK3 and related research on mitochondrial gene expression

Disease Connection

Parkinson's Disease

Phenotype(s)

MGI:3702932
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Slc6a3-cre mice.

Reference(s)

Ekstrand MI, Terzioglu M, Galter D, Zhu S, Hofstetter C, Lindqvist E, Thams S, Bergstrand A, Hansson FS, Trifunovic A, Hoffer B, Cullheim S, Mohammed AH, Olson L, Larsson NG, Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1325-30

Kearns-Sayre Syndrome

Phenotype(s)

MGI:2177634
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ckmm-cre mice.

Reference(s)

Wang J, Wilhelmsson H, Graff C, Li H, Oldfors A, Rustin P, Bruning JC, Kahn CR, Clayton DA, Barsh GS, Thoren P, Larsson NG, Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet. 1999 Jan;21(1):133-7

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