C1qa-KO

Nomenclature

C57BL/6Smoc-C1qaemSmoc

Cat. NO.

NM-KO-210110

Strain State

Repository Live

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Gene Summary

Gene Symbol
C1qa

Synonyms

C1q; AI255395

NCBI ID

12259

MGI ID

88223

Ensembl ID

ENSMUSG00000036887

Pubmed

C1qa

Human Ortholog

C1QA

Model Description

exon 3 of C1qa gene was deleted to generate C1qa knockout mice.

Disease Connection

Epilepsy

Phenotype(s)

MGI:4452482

Reference(s)

Chu Y, Jin X, Parada I, Pesic A, Stevens B, Barres B, Prince DA, Enhanced synaptic connectivity and epilepsy in C1q knockout mice. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7975-80

Systemic Lupus Erythematosus

Phenotype(s)

MGI:2384126

Reference(s)

Botto M, Dell'Agnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, Loos M, Pandolfi PP, Walport MJ, Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies [see comments]. Nat Genet. 1998 May;19(1):56-9

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