Syn1-KO

Nomenclature

C57BL/6Smoc-Syn1em1Smoc

Cat. NO.

NM-KO-191042

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol
Syn1

Synonyms

Syn-1， Syn1-S

NCBI ID

20964

MGI ID

98460

Ensembl ID

ENSMUSG00000037217

Pubmed

Syn1

Human Ortholog

SYN1

Model Description

Exon 4 of Syn1 gene was deleted to generate Syn1 knockout mice.
Research Application：Nervous system, CNS synapse formation and transmission, X-linked disease (such as Rett syndrome)

Disease Connection

Epilepsy

Phenotype(s)

MGI:5698534
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Syn2-KO(NM-KO-201079) and Syn3-KO(NM-KO-2112673) mice.

Reference(s)

Ketzef M, Kahn J, Weissberg I, Becker AJ, Friedman A, Gitler D, Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice. Neuroscience. 2011 Aug 25;189:108-22

Autism Spectrum Disorder

Phenotype(s)

MGI:5517482

Reference(s)

Greco B, Manago F, Tucci V, Kao HT, Valtorta F, Benfenati F, Autism-related behavioral abnormalities in synapsin knockout mice. Behav Brain Res. 2013 Aug 15;251:65-74

You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Customizing Mouse Models: Delivering in 100 Days to Speed Up Your Research!

At GenoBioTX, we understand that the lengthy wait times for gene-modified mouse models can hinder your research progress. Traditional methods often require 6-9 months, leading to delays and increased costs. That’s why we’re thrilled to introduce our innovative service designed to streamline this process and deliver results faster.

Learn more