hGCGR

Nomenclature

C57BL/6Smoc-Gcgrem(hGCGR)Smoc

Cat. NO.

NM-HU-215004

Strain State

Repository Live

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Gene Summary

Gene Symbol
Cxcr5

Model Description

The endogenous mice Gcgr gene was replaced by human GCGR gene.

Validation Data

image.png

Fig1. Detection of GCGR expression in liver by RT-PCR. 

Wild type: only one band at 589 bp with primers F1/R1(mGcgr);

Homozygous: only one band at 501 bp with primers F2/R2(hGCGR).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png


Fig2. Detection of hGCGR expression in hGCGR Mice by WB. 

Abbr. M,marker; HO, homozygous; WT, wild type.

Note. The anti-human GCGR Antibody cross-reacted with mouse GCGR and humanized GCGR.

image.png

Fig3. Detection of hGCGR expression in Kidney in hGCGR KI mice

Note. The anti-human GCGR antibody cross-reacted with mouse GCGR and humanized GCGR.

image.png

Fig4. Detection of hGCGR expression in Liver in hGCGR KI mice.

Note. The anti-human GCGR antibody cross-reacted with mouse GCGR and humanized GCGR.




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