hAPOE4
Nomenclature
C57BL/6Smoc-Apoetm2(hAPOE4)Smoc
Cat. NO.
NM-HU-190002
Strain State
Repository Live
Gene Summary
Gene Symbol
Apoe
Model Description
This APOE4 humanized mouse model was established by replacing the mouse Apoe gene coding exons and introns with the human APOE4 corresponding sequence by homologous recombination.
Validation Data
Fig1. Genotyping of WT 、KO & Humanized mice by PCR.
Primer P1/2 Wild type = 342 bp
Primer P3/4 mutant = 332 bp
M：100bp Plus DNA ladder.
Fig2. Detection of human APOE4 expression in Cerebellum in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig3. Detection of human APOE4 expression in Cornu ammonis 1(CA1) in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig4. Detection of human APOE4 expression in Cornu ammonis 3(CA3) in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
Fig5. Detection of human APOE4 expression in Dentate Gyrus(DG) in hAPOE4 knockin mice by IHC.
Brian were collected from wild-type mice and HO hAPOE4 mice, and analyzed by IHC with anti-human APOE4 antibody.
Abbr. HO, homozygous; WT, wild type.
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