hMC4R

Nomenclature

C57BL/6Smoc-Mc4rem1(hMC4R)Smoc

Cat. NO.

NM-HU-233876

Strain State

Repository Live

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Gene Summary

Gene Symbol
Mc4r

Model Description

The endogenous mouse Mc4r gene was replaced by human MC4R gene.

Validation Data

image.png

Fig.1 Detection of MC4R expression in brain by RT-PCR. 

Wild type: only one band at 264 bp with primers F1/R1(mMc4r);

Homozygous: only one band at 342 bp with primers F2/R2(hMC4R).

Abbr. M, DNA marker; HO, homozygous; WT, wild type.

image.png

Fig.2 Detection of human MC4R expression in brain in hMC4R mice by WB. 

Abbr. M, marker; WT, wild type; HO, Homozygous.

Note. The anti-human MC4R antibody cross-reacted with mouse MC4R and humanized MC4R.


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