Ccr2-IRES-DTRGFP

Nomenclature

C57BL/6Smoc-Ccr2em1(IRES-DTRGFP)Smoc

Cat. NO.

NM-KI-210102

Strain State

Repository Live

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Gene Summary

Gene Symbol
Ccr2

Synonyms

Ckr2; Ccr2a; Ccr2b; Ckr2a; Ckr2b; mJe-r; Cmkbr2; Cc-ckr-2

NCBI ID

12772

MGI ID

106185

Ensembl ID

ENSMUSG00000049103

Pubmed

Ccr2

Human Ortholog

CCR2

Model Description

IRES-DTRGFP expression cassette was knocked into the Ccr2 gene .

Validation Data

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Fig1. Analysis of GFP expression in the Ccr2-IRES-DTRGFP mice by FACS. The expression of GFP could be detected in CCR2+ and CD11b+ cells in peripheral blood of the heterozygous KI mice.

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Fig2. Analysis of CCR2+/CD11b+ cells proportion and GFP level in Ccr2-IRES-DTRGFP mice by FACS. The heterozygous KI mice were treated with DT (qd x 3 days).After 2 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells in the peripheral blood were decreased, and the level of GFP positive cells also decreased. After 4 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells returned to normal, and the level of GFP positive cells also returned to normal.

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