Cd4-IRES-DTRGFP
Nomenclature
C57BL/6Smoc-Cd4em5(IRES-DTREGFP)Smoc
Cat. NO.
NM-KI-190121
Strain State
Repository Live
Gene Summary
Gene Symbol
Cd4
Model Description
Validation Data
Figure 1. EGFP expression analysis in PBMC of CD4-IRES-DTR-EGFP heterozygous mice by FACS. (In collaboration with CrownBio).
Figure2. The percent of CD4+ T cells and other immune cells in peripheral blood of CD4-IRES-DTR-EGFP mice were detected by FACS. (In collaboration with CrownBio)
The C57BL/6 mice and CD4-IRES-DTR-EGFP mice were injected with diphtheria toxin, the results indicated that CD4+ T cells and Tregs of CD4-IRES-DTR-EGFP mice were depleted and meanwhile the amount of CD8+ T cells increased.
Figure3. The growth of MC38 tumors in CD4-IRES-DTR-EGFP mice and C57BL/6 mice. (In collaboration with CrownBio)
Heterozygous CD4-IRES-DTR-EGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. The CD4-IRES-DTR-EGFP mice were injected with diphtheria toxin once in two days.
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