Foxp3-IRES-DTRGFP

Nomenclature

C57BL/6Smoc-Foxp3em3(IRES-DTREGFP)Smoc

Cat. NO.

NM-KI-190046

Strain State

Repository Live

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Gene Summary

Gene Symbol
Foxp3

Synonyms

sf; JM2; scurfin

NCBI ID

20371

MGI ID

1891436

Ensembl ID

ENSMUSG00000039521

Pubmed

Foxp3

Human Ortholog

FOXP3

Model Description

A IRES-DTREGFP expression cassette was knocked into the Foxp3 gene stop codon site.
Research Application：DTR mouse

Validation Data

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Fig1. Expression of GFP on Tregs in Blood and Spleen in Foxp3-IRES-DTRGFP KI mice. 

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Fig2. Percentages of Tregs in the peripheral blood and spleen of Foxp3-IRES-DTRGFP KI mice treated with diphtheria toxin (DT).

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Fig3. The percent of  Treg+ and other immune cells in peripheral blood of MC38 tumor-bearing  Foxp3-IRES-DTRGFP mice is detected by FACS. (In collaboration with CrownBio) 

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Fig4. The percent of  Treg+ and other immune cells in spleen and tumor of MC38 tumor-bearing  Foxp3-IRES-DTRGFP mice is detected by FACS. (In collaboration with CrownBio) 

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Fig5.  The growth of MC38 tumors in Foxp3-IRES-DTRGFP mice and C57BL/6 mice. (In collaboration with CrownBio) 

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