Cd8a-IRES-DTRGFP
Nomenclature
C57BL/6Smoc-Cd8aem2(IRES-DTREGFP)Smoc
Cat. NO.
NM-KI-190045
Strain State
Repository Live
Gene Summary
Gene Symbol
Cd8a
Model Description
Validation Data
EGFP expression
Fig1. Validation EGFP expression in PBMC by FACS.(Cooperation with CrownBio)
Validation data of DTR function
Heterozygous CD8a-IRES-DTRGFP mice and C57BL/6 mice were inoculated with MC38 colon cancer cells. After the tumors grew to 100 mm3, the CD8a-IRES-DTRGFP mice were injected with Diphtheria toxin.
Fig2. The growth of MC38 tumors in Heterozygous CD8a-IRES-DTRGFP mice and C57BL/6 mice. (Cooperation with CrownBio)
Fig3. The percent of CD8+ T cell in peripheral blood of MC38 tumor-bearing CD8a-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS. (Cooperation with CrownBio)
Fig4. The percent of CD8+ T cell in peripheral blood of MC38 tumor-bearing CD8a-IRES-DTRGFP mice and C57BL/6 mice is detected by FACS. Nearly complete depletion was achieved only after 1 dose administration of DT and the depletion effect lasted to day 14.(Cooperation with CrownBio)
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