BALB/c Nude
Nomenclature
BALB/cAnSmoc-Foxn1nu/Smoc
Cat. NO.
SM-014
Strain State
Repository Live
Gene Summary
Gene Symbol
Foxn1
Model Description
This strain carries a Foxn1nu mutation on the BALB/c background which will lead to T cell deletion. At the same time, the response to thymus-dependent antigens is limited, resulting in impaired B cell function while NK cells, macrophages, and antigen-presenting cells function normally. The complement activity is normal as well. Hair dysplasia causes aberrant hair growth in which the majority of the hair cannot protrude from the surface, resulting in a naked mouse phenotype.
Validation Data
Fig1. Body weight growth curve of BALB/c Nude (n=30)
Fig2. Complete deletion of T, B cells of BALB/c Nude.
Fig3. Subcutaneous xenograft tumor growth in BALB/c Nude.
Fig4. Blood routine tests in BALB/c Nude.
Fig5. Blood biochemistry in BALB/c Nude.
Table 1. BALB/c Nude xenograft cell lines
You may also like
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
Learn moreOur vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
Learn more
