Ccr2-IRES-DTRGFP

Nomenclature

C57BL/6Smoc-Ccr2em1(IRES-DTRGFP)Smoc

Cat. NO.

NM-KI-210102

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Official Symbol
Ccr2

Model Description

IRES-DTRGFP expression cassette was knocked into the Ccr2 gene .

Validation Data

5.png

Fig1. Analysis of GFP expression in the Ccr2-IRES-DTRGFP mice by FACS. The expression of GFP could be detected in CCR2+ and CD11b+ cells in peripheral blood of the heterozygous KI mice.

6.png

Fig2. Analysis of CCR2+/CD11b+ cells proportion and GFP level in Ccr2-IRES-DTRGFP mice by FACS. The heterozygous KI mice were treated with DT (qd x 3 days).After 2 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells in the peripheral blood were decreased, and the level of GFP positive cells also decreased. After 4 days of drug withdrawal, the proportion of CCR2+ and CD11b+ cells returned to normal, and the level of GFP positive cells also returned to normal.


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more