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Strain State

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Gene Summary

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Model Description

Exon2-3 of B2m gene were deleted to generate Ifngr1 knockout mice.
Research Application:immune system

Validation Data


Fig1 . There are few CD8+ cytotoxic T-cells and increase in CD4+ T-cells in B2M knockout mice. Immune responses involving CD8+T-cells are severely deficient providing a model to assess the role of CD8+ cells and class I MHC in various experimental systems. 


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