hCD4

Nomenclature

C57BL/6Smoc-Cd4em1(hCD4) Smoc

Cat. NO.

NM-HU-00115

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Cd4

Model Description

The endogenous mouse Cd4 gene was replaced by human CD4 gene .
Research Application:Immunotherapy,cancer research,drug screening

Validation Data

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Fig 1. Flow cytometric analysis of the T cell subtype proportions in peripheral blood from control and the humanized CD4 mouse model. 

 A Lymphocyte dot plots. The gate for lymphocytes is indicated.   B Statistical analyses of the CD8+ T cell and CD4+ T cell  in the indicated groups. *P<0.05,**P<0.01.

CD4-hu-3.png

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Fig2. Flow cytometric analysis of the T cell subtype proportions in thymus from control and the humanized CD4 mouse model. A Lymphocyte dot plots. The gate for lymphocytes is indicated.   B Statistical analyses of the CD8+ T cell and CD4+ T cell  in the indicated groups. *P<0.05.

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Fig3. Expression characterization of hCD4 in hCD4 KI mice.


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