hCTLA-4/4-1BB
Nomenclature
C57BL/6Smoc-Ctla4em1(hCTLA4) Tnfrsf9em1(hTNFRSF9) /Smoc
Cat. NO.
NM-HU-18020
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
CTLA4
Gene Symbol
Tnfrsf9
Model Description
This CTLA4 and 4-1BB double knockin strain is established by crossing CTLA4-HU and 4-1BB-HU mice together. These double double knockin mouse models can be useful for evalueting the efficacy of potential immunotherapy drug combinations.
Research Application：Immunotherapy,cancer research,drug screening
*Literature published using this strain should indicate: hCTLA-4/4-1BB mice (Cat. NO. NM-HU-18020) were purchased from Shanghai Model Organisms Center, Inc..
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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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Milestones
Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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