MC38-hCD47/hPD-L1

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Strain Information

Cell Line

MC38-Cd274em1(hPDL1)Cd47em1(hCD47)/Smoc

Cat. NO.

NM-S13-TM07

Model Description

The endogenous mouse Cd274(also known as PD-l1)  and Cd47 gene was replaced by human PDL1 and CD47 gene.

Strain State

Validation of pharmacodynamic assays completed

Validation Data

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Figure 1. hCD47/hPDL1 expression in wild-type MC38 and MC38-hCD47/hPDL1 cell lines.

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Figure 2. Tumor growth curve of MC38-hCD47/hPDL1 syngeneic model (n=4).

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Figure 3. The expression of hCD47/hPDL1 in humanized modified tumors by FACS.

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Figure 4. Antitumor activity of Bispecific-antibody in two different treatment group (n=6).

Related Strain(s)

MC38-hPD-L1/hCLAUDIN 18.2
Cell Line：

MC38-hPD-L1/hCLAUDIN 18.2

Cat. NO.：NMC-230113
CT26-hPD-L1/hCLAUDIN 18.2
Cell Line：

CT26-hPD-L1/hCLAUDIN 18.2

Cat. NO.：NMC-230112
3T3-L1-Hif3a-KO
Cell Line：

3T3-L1-Hif3a-KO

Cat. NO.：NMC-230111
CT26-hIL13RA2
Cell Line：

CT26-hIL13RA2

Cat. NO.：NM-S24A-TM30
B16F10-hPDL1-Sirpa-KO
Cell Line：B16F10-hPDL1-Sirpa-KO
Cat. NO.：NMC-230067

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