H22-hPD-L1
Strain Information
Validation Data
Figure 1. Expression of human PD-L1 on H22-hPD-L1 cells was confirmed by flow cytometry.
H22-hPD-L1 cells and wild type H22 cells were stained with species-specific anti-PD-L1 antibodies. FACS analysis shows that human PD-L1 but not mouse PD-L1 was exclusively detectable on H22-hPD-L1 cells.
Figure 2. In vivo tumor growth curves in humanized H22-hPD-L1 syngeneic model.
BALB/c mice were subcutaneously injected 5×106 H22-hPD-L1 cells compared with wild type H22 cells as control. Tumor growth was monitored by measuring tumor size from day 6 after subcutaneous implantation.
Data shows that there were no significant differences between H22-hPD-L1 cells and wild type H22 cells in either tumorigenicity or tumor growth.
Figure 3. FACS analysis of PD-L1 expression on tumor cells derived from humanized H22-hPD-L1 syngeneic model with species-specific anti-PD-L1 antibodies.
Data shows that human PD-L1 knock-in tumor exclusively express human PD-L1 but not mouse PD-L1.
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