H11-pThy1-hPSEN1-IRES-tdTomato
Nomenclature
C57BL/6Smoc-Igs2em1(pThy1-PSEN1-IRES-tdTomato-WPRE-pA)Smoc
Cat. NO.
NM-KI-18049
Strain State
Embryo cryopreservation
Gene Summary
Gene Symbol
Igs2
Model Description
A Thy1 promoter-PSEN1-IRES-tdTomato-WPRE-polyA cassette was knocked into the Igs2 locus (Hipp11 or H11; an intergenic region on chromosome 11 [cytoband A1 at ~3cM between the Eif4enif1 and Drg1 loci] reported to support high-level global gene expression in conjunction with the CAG (CAGGS) promoter and a higher rate of mitotic/interchromosomal recombination compared to Gt(ROSA)26Sor) .
Research Application：Alzheimer's research
*Literature published using this strain should indicate: H11-pThy1-hPSEN1-IRES-tdTomato mice (Cat. NO. NM-KI-18049) were purchased from Shanghai Model Organisms Center, Inc..
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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Milestones
Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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