Mefv-hMEFV*V726A

Nomenclature

C57BL/6Smoc-Mefvem1(hMEFV-V726A)Smoc

Cat. NO.

NM-KI-200221

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Mefv

Synonyms

FMF， pyrin， TRIM20

NCBI ID

54483

MGI ID

1859396

Ensembl ID

ENSMUSG00000022534

Pubmed

Mefv

Human Ortholog

MEFV

Model Description

Exon 7-10 of the endogenous mouse Mefv gene was replaced by human mutation gene (exon7-10).
Research Application：Familial Mediterranean fever

Disease Connection

Familial Mediterranean Fever

Phenotype(s)

MGI:5007929

Reference(s)

Chae JJ, et al., Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1beta Activation and Severe Autoinflammation in Mice. Immunity. 2011 May 27;34(5):755-68

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