CAG-hACE2-IRES-Luc-Tg
Nomenclature
C57BL/6Smoc-Tgtn(CAG-human ACE2-IRES-Luciferase-WPRE-polyA)Smoc
Cat. NO.
NM-TG-200002
Strain State
Repository Live
Gene Summary
Gene Symbol
Model Description
Validation Data
Figure 1. Luciferase expression of the CAG-hACE2-IRES-Luciferase transgenic mice.
Figure 2. Western blot analysis of ACE2 protein from the CAG-hACE2-IRES-Luciferase transgenic mice.
Figure 3. Virus titers in the lungs of hACE2 Tg mice after SARS-CoV-2 infection. Groups of hACE2 Tg mice and wild type mice were inoculated with the same dose of SARS-CoV-2, the result shows that hACE2 Tg mice were highly susceptible to SARS-CoV-2 infection.
Figure 4. Body weight change in hACE2 Tg mice after drug treatment.
Figure 5. The viral load in the lung tissues of hACE2 Tg mice after drug treatment.
Publications
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