hFCRN/hALB(SD)

Nomenclature

SD-Fcgrtem1(hFCGRT)Albem3(hALB)Smoc

Cat. NO.

NR-HU-233317

Strain State

Repository Live

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Gene Summary

Model Description

The hALB(SD)(NR-HU-200001) was crossed with hFCRN(SD)(NR-HU-200002) to generate hFCRN(SD)/hALB(SD) mice.

Validation Data

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Fig1. Detection of ALB expression in serum by blood biochemical analysis (n=4). 

Abbr. HO, homozygous; WT, wild type.

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Fig2. Detection of hALB and rat ALB expression in plasma by ELISA (n=3). 

Abbr. HO, homozygous; WT, wild type.

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Fig3. Expression characterization of hFCRN in hALB/hFCRN dKI rat by Western blot. (Arrow indicates expected molecular weight and asterisk indicates a nonspecific band)   

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Fig4. Blood concentration curve of test articles in hFcRn/hALB dKI rats. 

In hFcRn/hALB dKI rats, the half-life time: TA-N434A > TA-YTE > TA. (In cooperation with the third party) 

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Fig5. PK study of Keytruda in hFCRN rat.

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Fig6. PK study of Cyramza in hFCRN rat.

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