Th-IRES-CreERT2

Nomenclature

C57BL/6Smoc-Them1(IRES-creER)Smoc

Cat. NO.

NM-KI-200082

Strain State

Repository Live

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Gene Summary

Gene Symbol
Th

Synonyms

-

NCBI ID

21823

MGI ID

98735

Ensembl ID

ENSMUSG00000000214

Pubmed

Th

Human Ortholog

TH

Model Description

A IRES-creER expression cassette was knocked into the Th gene stop codon site.
Research Application：Cre recombinase tool, dopaminergic neurons in the brain

Validation Data

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Fig1. Cre mediated recombination in brain of ThCreERT2/+;Rosa26tdTomato/+ mouse. (VTA: ventral tegmental area)

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Fig2. Detection of tdTomato(red) in various tissues of ThCreERT2/+;Rosa26tdTomato/+ mouse. Expression tissues include: brain, islet. A few cells expressed in spinal cord, pituitary gland, small intestine, colon, skin, thymus and adrenal gland. Tissues that unexpressed include eye, heart, lung, liver, stomach, salivary glands, brown fat, kidney, spleen, muscle. Tamoxifen induction began at 49 days of age, with testing at 58 days. (For more detailed information please contact our technical advisor.) 

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