hCCL4

Nomenclature

C57BL/6Smoc-Ccl4em1(hCCL4)/Smoc

Cat. NO.

NM-HU-210013

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
Ccl4

Model Description

The endogenous mice Ccl4 gene was replaced by human CCL4 gene
Research Application:drug screening

Validation Data

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Fig1. Detection of CCL4 expression in small intestine, spleen and  thymus by RT-PCR. Wild type: only one band at 242 bp with primers F1/R1(mCcl4); Homozygous: only one band at 144 bp with primers F2/R2(hCCL4); Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

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Fig 2. Detection of hCCL4 expression in plasma by ELISA. Abbr. HO, homozygous; HE, heterozygous; WT, wild type. Note. hCCL4 and C57BL/6 mice were i.p. injected with LPS(20mg/kg) for 6h.


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