hIL2RB

Nomenclature

C57BL/6Smoc-Il2rbtm1(hIL2RB)/Smoc

Cat. NO.

NM-HU-2000055

Strain State

Embryo cryopreservation

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Gene Summary

Gene Symbol
IL2RB

Model Description

The endogenous mouse Il2rb gene was replaced by human IL2RB gene.
Research Application:Cytokine humanization model;drug screening

Validation Data

NM-HU-2000055 hIL2RB.png

Fig1. Analysis of IL2RB gene expression in the liver by RT-PCR.

Mouse Il2rb mRNA was detectable by P1/2(511bp), human IL2RB mRNA was detectable by P1/3(513bp), 

M:100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mouse expresses both human IL2RB and mouse Il2rb in the liver.


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