hC3

Fig1. Detection of C3 expression in liver by RT-PCR. 

Wild type: only one band at 359 bp with primers F1/R1(mC3);Heterozygous: one band at 359 bp with primers F1/R1(mC3) and one band at 357 bp with primers F2/R2(hC3); 

Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.

Fig2. Detection of hC3 expression in serum by ELISA. 

Abbr. Het, heterozygous; WT, wild type. Note: Data from the collaborator.

Fig3. Detection of hC3 expression in serum by ELISA. 

Note: The human Complement C3 ELISA Kit (ab108823) specifically recognized humanized C3.

Abbr. HO, homozygous; WT, wild type.

Fig4. The C3hu/hu mice showed inflammation in the portal region and bile duct hyperplasia (100× and 400×).

Fig5. The C3hu/hu mice showed glomerular sclerosis, glomerular atrophy and inflammation of the capillary tufts area (100× and 400×).

Fig6. Body Weight of C3hu/hu mice (n=12/group).

Abbr. HO, homozygous; HE, heterozygous; WT, wild type.

Fig7. Survival curve of C3hu/hu mouse (n=12/group).

Abbr. HO, homozygous; HE, heterozygous; WT, wild type.

Fig8. Serum Biochemistry of C3hu/hu mice (n=5/group).

Abbr. HO, homozygous; HE, heterozygous; WT, wild type.

Fig9. Serum Biochemistry of C3hu/hu mice (n=5/group, a different biochemical analyzer was used than in Fig8).

Abbr. HO, homozygous; HE, heterozygous; WT, wild type.

Fig10. Urinalysis of C3hu/hu mice.

Abbr. HO, homozygous; HE, heterozygous; WT, wild type.