Cdk4-KO
Nomenclature
C57BL/6Smoc-Cdk4em1Smoc
Cat. NO.
NM-KO-190614
Strain State
Developing
Gene Summary
Gene Symbol
Cdk4
Model Description
Exon 3-7 of Cdk4 gene was deleted to generate Cdk4 knockout mice.
Research Application：The protein encoded by this gene is a member of the Ser/Thr protein kinase family.It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb).
*Literature published using this strain should indicate: Cdk4-KO mice (Cat. NO. NM-KO-190614) were purchased from Shanghai Model Organisms Center, Inc..
Disease Connection
Type 1 Diabetes Mellitus
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