Apoe-KO(2)

Nomenclature

C57BL/6Smoc-Apoeem5Smoc

Cat. NO.

NM-KO-190565

Strain State

Repository Live

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Gene Summary

Gene Symbol
Apoe

Synonyms

Apo-E; AI255918

NCBI ID

11816

MGI ID

88057

Ensembl ID

ENSMUSG00000002985

Pubmed

Apoe

Human Ortholog

APOE

Model Description

Apoe-KO(2) mice (Stock No.NM-KO-190565) carry a knockout allele derived from the targeted deletion of exon 2-4. While Apoe-KO mice (Stock No.NM-KO-00033) have been pulled from shelves for some reasons.
Research Application：Atherosclerosis,hyperlipidemia,hypercholesterolemia,cerebral infarction,AD,chronic hepatitis etc.

Disease Connection

Coronary Artery Disease

Phenotype(s)

MGI:5558016
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Scarb1-KO(NM-KO-201876) mice.

Reference(s)

Tsukamoto K, Mani DR, Shi J, Zhang S, Haagensen DE, Otsuka F, Guan J, Smith JD, Weng W, Liao R, Kolodgie FD, Virmani R, Krieger M, Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17023-8

Familial Combined Hyperlipidemia

Phenotype(s)

MGI:4354296
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Lpl-KO(NM-KO-201300) mice.

Reference(s)

Xian X, Ding Y, Zhang L, Wang Y, McNutt MA, Ross C, Hayden MR, Deng X, Liu G, Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice. Biochem Biophys Res Commun. 2009 Aug 7;385(4):563-9

Abdominal Obesity-Metabolic Syndrome

Phenotype(s)

MGI:5428435
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Cyp19A1-KO(NM-KO-2102244) mice.

Reference(s)

Scott NJ, Cameron VA, Raudsepp S, Lewis LK, Simpson ER, Richards AM, Ellmers LJ, Generation and characterization of a mouse model of the metabolic syndrome: apolipoprotein E and aromatase double knockout mice. Am J Physiol Endocrinol Metab. 2012 Mar;302(5):E576-84

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