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U-GEMMs

About 42,208 results
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hABCC2

모델명：C57BL/6Smoc-Abcc2tm1(hABCC2)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-200254

The endogenous mice Abcc2 gene was replaced by human ABCC2 gene.

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hB7H3

모델명：C57BL/6Smoc-Cd276tm2(hB7H3)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-00107

The endogenous mouse Cd276 gene was replaced by human CD276 gene.

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h4-1BB(2)/hOX40

모델명：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Tnfrsf4em1(hTNFRSF4)/Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-200272

hTNFRSF9(NM-HU-190077) was crossed with hOX40(NM-HU-00041)to generate h4-1BB(2)/hOX40 mice

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hCTLA-4

모델명：C57BL/6Smoc-Ctla4em1(hCTLA4) Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-00014

The endogenous mouse Ctal4 gene was replaced by human CTLA4 gene. While hCTLA4(2)(Stock No.NM-HU-190038) mice function similarly to hCTLA4 mice,for more detailed information please contact our technical advisor.

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Rag2-KO(Rag2-EGFP)

모델명：B6;129S-Rag2tm1(loxP-EGFP-PolyA-loxP-Neo-loxP)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-00070

A loxP-EGFP-PolyA-loxP-Neo-loxP expression cassette was knocked into the Rag2 gene start codon site. As a Rag2 knockout mouse model, this stain can be used in subcutaneous inoculation of liver cancer tissues and tumor cells. Tumors can esaily form and grow. The amount of T and B lymphocytes in peripheral blood of mice was extremely low tested by FACS, which was comparable to or lower than that of Nude mice, and there was a significant difference compared with wild type mice. The pathological sections of HE staining of tumor tissues showed that the tumor sections of Rag2 KO mice and Nude mice were similar. This strain has the potential to replace Nude, NOD-SCID mice as a tumor-bearing mouse model.

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CAG-LSL-dCas9-SPH-Tg

모델명：C57BL/6Smoc-Tg(CAG-LSL-dCas9-SPH)Smoc
모델 상태：Repository Live | 카탈로그：NM-TG-00025

Cre-dependent SunTag-p65-HSF1 (SPH) transgenic mice were generated with piggyBac transposon system in F1 zygotes and crossed with wild type C57BL/6 mice., SPH transgenic mouse containing HA-tagged dCas9 fused with 10xGCN4, which is linked with p65-HSF1 and EGFP in tandem via P2A and T2A respectively. The transgene is driven by the ubiquitous CAG promoter and interrupted by a loxP-stop-loxP (LSL) cassette to render Cas9 expression inducible by the Cre recombinase. Expression of dCas9 can be detected using primary antibody: rabbit monoclonal antibody to HA-tag (1:1000, #3724, CST45) and secondary antibody: goat anti-rabbit Alexa Fluor 488 (1:1000, #A-11034, Thermo Fisher).

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Alb-2A-DTRGFP(NMG)

모델명：NOD-Prkdcscid Il2rgem1Albem1(2A-DTRGFP)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-215047

2A-DTRGFP expression cassette was knocked into the Alb gene.

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Aplnr-2A-DreERT2

모델명：C57BL/6Smoc-Aplnrem1(2A-DreERT2)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-00132

A 2A-DreERT2-SV40polyA coexpression cassette is inserted befor the stop codon of mouse Aplnr gene via homologous recombination to establish a tamoxifen inducible Aplnr-DreERT2 tool stain. This strain can be used to knockout target gene in Aplnr+ cells after tamoxifen treatment when crossed with mice which carry rox sites flanking target gene.

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B2m-KO(NMG)

모델명：NOD.Cg-PrkdcscidIl2rgem1SmocB2mem1Smoc
모델 상태：Repository Live | 카탈로그：NM-NSG-002

This B2m knockout mouse model was obtained by knocking out the exon 2-3 region of mouse B2m gene on the background of NMG mouse.

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hC5AR1

모델명：C57BL/6Smoc-C5ar1em1(hC5AR1)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-204989

The endogenous mice C5ar1 gene was replaced by human C5AR1 gene.

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