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U-GEMMs

About 42,193 results
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NMG

모델명：NOD.Cg-PrkdcscidIl2rgem1Smoc
모델 상태：Repository Live | 카탈로그：NM-NSG-001

Prkdc and Il2rg genes were both knocked-out in NOD mice.  Lacking mature T, B and NK cells Low immune rejection against human cells and tissues Good tumorigenicity so that a small number of cells can form tumors. Significant improvement in the survival of transplanted human cells and tissues Suitable for the transplantation of human hematopoietic stem cells and the preparation of humanized mouse models Suitable as the carrier mice for the transplantation of heterologous cells and tissues

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hPD-1

모델명：C57BL/6Smoc-Pdcd1em1(hPDCD1) /Smoc
모델 상태：Repository Live | 카탈로그：NM-HU-00015

The endogenous mouse Pdcd1 gene was replaced by human PDCD1(PD-1) gene  .

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hPD-L1

모델명：C57BL/6Smoc-Cd274em1(hPD-L1)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-00062

The endogenous mouse Cd274(also known as PD-L1) gene was replaced by human PD-L1 gene .  While hPD-L1(2)(Stock No.NM-HU-190039) mice function similarly to hPD-L1 mice,for more detailed information please contact our technical advisor.

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Kras-LSL-G12D

모델명：C57BL/6Smoc-Krasem4(LSL-G12D)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-190003

exon2 of Kras were replaced by loxp-stop-loxp and exon2 containing G12D. When crossed with a Cre recombinase-expressing strain, this strain is useful in studies of cancer and development.

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Alb-CreERT2

모델명：B6.129S-Albtm1.1(CreERT2)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-00002

Exons 1-7 were replaced by CreERT2 and a loxp neo casette. The KI mice have a tamoxifen-inducible cre-mediated recombination system.This strain has removed the Neo screening gene.

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CAG-hACE2-IRES-Luc-Tg

모델명：C57BL/6Smoc-Tgtn(CAG-human ACE2-IRES-Luciferase-WPRE-polyA)Smoc
모델 상태：Repository Live | 카탈로그：NM-TG-200002

The transgene is composed of a CAG-human ACE2-IRES-Luciferase-WPRE-polyA expression cassette under the control of CAG promter.

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R26-CAG-LSL-RSR-tdTomato-2A-DTR

모델명：C57BL/6Smoc-Gt(ROSA)26Sorem1(CAG-LSL-RSR-tdTomato-2A-DTR)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-190086

These mice harbor a CAG-LSL-RSR-tdTomato-2A-DTR cassette in the Rosa26 locus generated by homologous recombination.

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hACE2

모델명：C57BL/6Smoc-Ace2em3(hACE2-flag-Wpre-pA)Smoc
모델 상태：Repository Live | 카탈로그：NM-HU-200218

A human ACE2-flag-Wpre-pA expression cassette was knocked into the Ace2 gene start codon site via CRISPR/Cas9 mediated recombination.

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Cdkn2a-Luc-2A-tdTomato-2A-CreERT2

모델명：C57BL/6Smoc-Cdkn2aem(Luc-tdTomato-CreERT2)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-18039

A Luc-2A-tdTomato-2A-CreERT2-WPRE-pA cassette was fused in-frame with exon2 of Cdkn2a-201 transcript such that the exogenous proteins would be translated followed by the first 62aa of Cdkn2a.

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h4-1BB(2)

모델명：C57BL/6Smoc-Tnfrsf9tm2(TNFRSF9)Smoc
모델 상태：Repository Live | 카탈로그：NM-HU-190077

The endogenous mouse Tnfrsf9 gene was replaced by human TNFRSF9(4-1BB) gene. While h4-1BB mice(Stock No.NM-HU-00099）have been pulled from shelves for some reasons.

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