hAppNL-G-F

Nomenclature

C57BL/6Smoc-Apptm3(hAppNL-G-F)/Smoc

Cat. NO.

NM-HU-2000088

Strain State

Embryo cryopreservation

Export PDF

Gene Summary

Gene Symbol
App

Model Description

The endogenous mouse App gene was replaced by human AppNL-G-F.
Research Application:Alzheimer's disease research

Validation Data

image.png

Fig1. Detection of APP expression in brain by RT-PCR.

image.png

Fig2. (A) β-Amyloid (6E10) staining of WT and hAPPNL-G-F mice at 1, 3 and 6 months (magnification, 40x and 100x). (B) Statistics of 6E10 positive plaque area.

image.png

Fig3. (A) Thioflavine S staining of WT and hAPPNL-G-F mice at 1, 3 and 6 months (magnification, 40x and 100x). (B) Statistics of ThiS positive plaque area.


You may also like

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

Learn more
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

Learn more