CAG-hACE2-IRES-Luc-Tg

Nomenclature

C57BL/6Smoc-Tgtn(CAG-human ACE2-IRES-Luciferase-WPRE-polyA)Smoc

Cat. NO.

NM-TG-200002

Strain State

Repository Live

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Gene Summary

Gene Symbol

Model Description

The transgene is composed of a CAG-human ACE2-IRES-Luciferase-WPRE-polyA expression cassette under the control of CAG promter.
Research Application:corona virus related research

Validation Data

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Figure 1. Luciferase expression of the CAG-hACE2-IRES-Luciferase transgenic mice.

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Figure 2. Western blot analysis of  ACE2  protein from the CAG-hACE2-IRES-Luciferase transgenic mice. 

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Figure 3. Virus titers in the lungs of hACE2 Tg mice after SARS-CoV-2 infection. Groups of hACE2 Tg mice and wild type mice were inoculated with the same dose of SARS-CoV-2, the result shows that hACE2 Tg mice were highly susceptible to SARS-CoV-2 infection.

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Figure 4. Body weight change in hACE2 Tg mice after drug treatment.

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Figure 5. The viral load in the lung tissues of hACE2 Tg mice after drug treatment. 



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