Nkx2-1-CreERT2

Nomenclature

C57BL/6Smoc-Nkx2-1em1(CreERT2-pA)Smoc

Cat. NO.

NM-KI-200123

Strain State

Sperm cryopreservation

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Gene Summary

Gene Symbol
Nkx2-1

Synonyms

T/EBP; Titf1; Ttf-1; Nkx2.1; AV026640

NCBI ID

21869

MGI ID

108067

Ensembl ID

ENSMUSG00000001496

Pubmed

Nkx2-1

Human Ortholog

NKX2-1

Model Description

A CreERT2-pA expression cassette was knocked into the Nkx2-1 gene start codon site. Nkx2-1, a key molecule in lung development, is expressed in adult bronchial and alveolar type Ⅱ epithelial cells. Besides, Nkx2-1 expression as a prognostic marker is also been applied to lung cancer research including lung adenocarcinoma.
Research Application：Cre recombinase tool

Validation Data

Fig. 1 Detection of tdTomato (red) in the pulmonary epithelial cells of Nkx2-1CreERT2/+; Rosa26tdTomato/+  mouse after tamoxifen treatment. CreERT2-mediated recombination in some of the bronchial and alveolar epithelial cells of Nkx2-1CreERT2/+; Rosa26tdTomato/+ mouse can be induced by tamoxifen. 

Fig. 2 Detection of tdTomato (red) in various tissues of Nkx2-1CreERT2/+; Rosa26tdTomato/+ mice after tamoxifen treatment. CreERT2-mediated recombination in the lung can be induced by tamoxifen. And tdTomato expression can not be observed in the pituitary gland, retina, heart, liver, stomach, colon,  intestine, kidney, pancreas, etc.

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